Spatial and memory circuit from Entorhinal cortex to Hippocampus
Title: Spatial and memory circuit from Entorhinal cortex to Hippocampus
Friedrich Miescher Institute for Biomedical Research, Switzerland
Hippocampus and Entorhinal cortex are the major components of spatial and memory circuit. Hippocampal place cells undergo remapping when the environment is changed. The mechanism of hippocampal remapping remains elusive but spatially modulated cells in the medial entorhinal cortex (MEC) have been identified as a possible contributor. Using pharmacogenetic and optogenetic approaches, we tested the role of MEC cells by examining in mice whether partial inactivation in MEC shifts hippocampal activity to a different subset of place cells with different receptive fields. Our results point to MEC input as an element of the mechanism for remapping in place cells. The MEC contains several discrete classes of GABAergic interneurons, but their specific contributions to spatial pattern formation in this area remain elusive. Through inactivation of sub population of MEC interneurons, we found distinct roles for PV and SOM interneurons in the local dynamics underlying periodic and aperiodic firing in spatially modulated cells of the MEC.